Respiratory Distress Syndrome (RDS) in premature infants
藥理
Pulmonary Surfactants
藥動學
1. CUROSURF is administered directly to the lung, where biophysical effects occur at the alveolar surface. 2. No human pharmacokinetic studies have been performed to characterize the absorption, biotransformation, or elimination of CUROSURF.
禁忌症
For those who have allergic reactions to the main ingredient or any excipients. 懷孕分類:This drug is not indicated for use in adults.
懷孕分類
This drug is not indicated for use in adults.
哺乳分類
This drug is not indicated for use in adults.
副作用
Common adverse reactions associated with the administration of CUROSURF include bradycardia, hypotension, endotracheal tube blockage, and oxygen desaturation.
劑量和給藥方法
1. Initial recommended dose is 2.5 mL/kg (200mg/kg) birth weight2. Up to two repeat doses of 1.25 mL/kg birth weight may be administered at approximately 12-hour intervals 3. Maximum total dose (initial plus repeat doses) is 5 mL/kg4. Administration :(1). For the first dose: 1.25 mL/kg (birth weight) per aliquot (2). For each repeated dose: 0.625 mL/kg (birth weight) per aliquotPreparation of the CUROSURF Suspension: 1. Remove the vial of CUROSURF suspension from a refrigerator at +2°C to +8°C and slowly warm the vial to room temperature before use.2. Gently turn the vial upside-down, in order to obtain a uniform suspension. DO NOT SHAKE.
小兒調整劑量
Please see the dosage and administration instructions for details.
腎功能調整劑量
There are no dosage adjustments provided in the manufacturer's labeling.
肝功能調整劑量
There are no dosage adjustments provided in the manufacturer's labeling.
安定性
1. Unopened, unused vials of CUROSURF suspension that have warmed to room temperature can be returned to refrigerated storage within 24 hours for future use. 2. Do not warm to room temperature and return to refrigerated storage more than once. 3. Protect from light.