Plasma expander transfusion; Adjunct - Traumatic shock

Dextran is colloid volume expander.

Distribution: Vd 6.5 liters.
Metabolism Sites and Kinetics: tissue.
Excretion: Renal Excretion (%) 50%.
Elimination Half-life: 41 minutes.
Hemodialysis: Dialyzable: No

Hypersensitivity to dextran or corn products, pulmonary edema, renal disease with severe oliguria or anuria, severe bleeding disorders, severe congestive heart failure.

C (FDA)

Infant risk cannot be ruled out (MDX), compatible with breastfeeding (WHO).

Blood coagulation disorder (prolonged coagulation times, thrombocytopenia, hematoma), transient liver enzyme elevations, alanine aminotransferase, flushing, erythema, or urticaria; a "strange" feeling, nephrotoxicity, pleural effusion, pulmonary edema.

Volume expansion/shock:IV: Dextran 40: Infuse 500 to 1,000 mL (~10 mL/kg) as rapidly as possible (maximum: 20 mL/kg/day for first 24 hours; 10 mL/kg/day thereafter); therapy should not be continued beyond 5 days.Pump prime: Varies with the volume of the pump oxygenator; generally, the solution is added in a dose of 10 to 20 mL/kg (or 1 to 2 g/kg); usual maximum total dose: 20 mL/kg (or 2 g/kg)

Shock: Infants, Children, and Adolescents: Initial: IV Bolus: 20 mL/kg over at least 5 minutes; repeat as needed based on response.Volume expansion (nonshock like conditions):Infants: IV: Infuse 5 mL/kg as rapidly as necessary; maximum daily dose: 20 mL/kg/day for first 24 hours, then 10 mL/kg/day thereafter; therapy should not be continued beyond 5 days.Children and Adolescents <50 kg: IV: Infuse 10 mL/kg as rapidly as necessary; maximum daily dose: 20 mL/kg/day for first 24 hours, then 10 mL/kg/day thereafter; therapy should not be continued beyond 5 days.Adolescents ?50 kg: IV: Infuse 500 to 1,000 mL (~10 mL/kg) as rapidly as necessary; maximum daily dose: 20 mL/kg/day for first 24 hours, then 10 mL/kg/day thereafter; therapy should not be continued beyond 5 days.Pump prime: Infants: IV: 5 mL/kg; usual maximum total dose: 20 mL/kg/day.Children: IV: 10 mL/kg; usual maximum total dose: 20 mL/kg/day.Adolescents: IV: 10 to 20 mL/kg; usual maximum total dose: 20 mL/kg/day.

Since dextrans are primarily eliminated by the kidney, dosage adjustment may be necessary in patients with renal insufficiency.

Use with extreme caution

Store at temperatures below 30°C.To prevent the precipitation of insoluble Dextran, please follow the precautions below:(1)Store in an area with minimal temperature fluctuations. Avoid placing near air conditioning vents or other locations with significant temperature changes.(2)Precipitation of insoluble Dextran is more likely to occur between the stopper and the inner wall of the bottle. Therefore, when stored in plastic bottles, it is recommended to keep the bottle lying horizontally whenever possible.【文字內容由仿單翻譯而來】