藥碼
PAN03
藥名
Pantoprazole 40 mg
英文商品名
Pantoloc 針 40 mg/Vial
中文商品名
保衛康治潰樂凍晶注射劑
螢幕名
Pantoloc 針 40 mg/Vial
劑型
Inj
規格
Inj 40 mg/Vial
成分
藥理分類
Antiulcer Proton-pump Inhibitors
健保碼
BC23306245
ATC碼
藥品圖片
外觀圖片
適應症
【藥品性質提示】
根據 2019 AGS Beers Criteria,本藥品為【潛在不適當用藥 (PIM)】,非下述情況之老年病患,不建議使用超過八周:潰瘍高風險族群(如長期使用口服類固醇、NSAID)、糜爛性食道炎(EE)、胃酸分泌過多、無法使用H2 antagonist者。

PPI Gastric and duodenal ulcers, moderate and severe reflux esophagitis; pathological gastric hyper-secretion
藥理
Pantoprazole is a potent inhibitor of gastric acid secretion. Animal and in vitro studies have demonstrated it to be comparable to or more potent than omeprazole, with less potential for interactions with P450 cytochromes and better acid stability.
藥動學
Pantoprazole is well absorbed. It undergoes little first-pass metabolism resulting in an absolute bioavailability of approximately 77%.
  • Protein binding: 98%.
  • Metabolism: Pantoprazole is extensively metabolized in the liver through the cytochrome P450 (CYP) system.
  • After administration of a single intravenous dose of 14C-labeled pantoprazole to healthy, normal metabolizer subjects, approximately 71% of the dose was excreted in the urine with 18% excreted in the feces through biliary excretion.
  • Half life: 1 hour.
  • 禁忌症
    Hypersensitivity to pantoprazole; Severe hepatic insufficiency; Cirrhosis
    懷孕分類
    B
    哺乳分類
    Pantoprazole is distributed into milk; discontinue nursing or the drug because of potential risk in nursing infants.
    副作用
    headache (1.3%), diarrhea (1.5%), dizziness (0.7%), pruritis (0.5%), and asthenia (0.3%)
    劑量和給藥方法
    Gastric ulcer, duodenal ulcer and reflux esophagitis: 40mg IV QD for 7-10 days
    Pathological gastric hyper-secretion: 80 mg IV Q12H, may increase to Q8H, MAX 240 mg/day
    小兒調整劑量
    腎功能調整劑量
    No dosage adjustment necessary.
    肝功能調整劑量
    1. Child-Turcotte-Pugh class A and B (IV, Oral): Use lowest effective indication-specific dose and minimize duration; maximum dose: 40 mg/day.
    2. Child-Turcotte-Pugh class C (IV, Oral): Use lowest effective indication-specific dose and minimize duration; maximum dose: 20 mg once daily or 40 mg every other day.
    安定性
    Reconstituted with N/S
    注射給藥指引
    給藥途徑
    IV (靜脈注射)、IVD (靜脈滴注)
    靜脈輸注液
    再生溶液:NS(仿單)。稀釋溶液:D5W、NS(仿單)、LR(micromedex)。
    每瓶稀釋液體積
    再生:10mL NS;稀釋:100mL NS、D5W (最終濃度:0.4 mg/mL)
    注射濃度
    給藥速率
    IV (靜脈注射):2-15分鐘(仿單)
    安定性
    Reconstituted with N/S
    注意事項
    相容:aminophylline、 bumetanide、 calcium gluconate、 cisatracurium、 esmolol、 morphine、 potassium chloride、vasopressin
    不相容:amiodarone、calcium chloride、dexmedetomidine、 diltiazem、 dobutamine、fentanyl、heparin、 labetalol、 lidocaine、 lorazepam、 magnesium sulfate、 midazolam、 milrinone、 nicardipine、 propofol、 sodium bicarbonate
    完整資訊請見重症常用藥品靜脈相容性表
    藥袋資訊
    臨床用途
    消化性潰瘍與胃食道逆流
    主要副作用
    脹氣、腹瀉、便秘、頭痛等
    泡製方法
    儲存方式
    請置於 15-30℃ 乾燥處儲存
    注意事項
    其他說明
    藥局 a2 | 小庫 A | 藥庫 注F12
    藥品外觀
    顏色
    形狀
    剝痕
    標記1
    標記2
    其他
    健保藥價
    119
    自費價
    158.27
    仿單
    資料庫
    健保給付規定