【藥品庫存】 藥品安全警訊 (藥品回收)食藥署今日 (2/13) 公告得時高凍晶注射劑400毫克，因為殘留類固醇，回收部分批號，本院使用之同成分藥品，產地、製造廠皆不同，不需回收。更新日期：2023/2/13。

Gram-positive infections
Surgical (orthopedic) prophylaxis

Antibiotic, Miscellaneous

Absorption
Tmax: (IM)2 hrs; (IV) end of infusion
Bioavailability: (IM)90%
Distribution
Protein binding, albumin: 87.6% to 90.8%
Vd: 0.7 to 1.4 L/kg
Excretion
Fecal: 2.7% unchanged (IV); 45% unchanged (oral)
Renal: 80% unchanged
Dialyzable: No
Elimination Half Life
Adults: 100 to 170 hours; Neonates: 40 hours; Pediatric (age 8 years): 58 hours

Hypersensitivity to teicoplanin or any component of the product

Fetal risk cannot be ruled out.

Infant risk cannot be ruled out

Common
Dermatologic: Erythema, Pruritus, Rash (1% to less than 10%)
Other: Fever (1% to less than 10%)
Serious
Dermatologic: Stevens-Johnson syndrome, Toxic epidermal necrolysis
Hematologic: Thrombocytopenia (0.1% to less than 1%)
Immunologic: Anaphylaxis (0.1% to less than 1%), Hypersensitivity reaction
Otic: Toxic deafness (0.1% to less than 1%)
Renal: Renal failure

Gram-positive infections:
Initial 6-12 mg/kg Q12H for 3 to 5 doses; Maintenance 6-12 mg/kg QD to achieve targeted trough concentration
Surgical (orthopedic) prophylaxis:
400 mg (or 6 mg/kg) given once at induction of anesthesia

Neonates and Infants <2 months:
(IV) Initial 16 mg/kg loading dose on day 1, followed by 8 mg/kg once daily starting on day 2
Infants ≥2 months and Children ≤12 years:
(IV) Initial 10 mg/kg every 12 hours for 3 doses, followed by 6 to 10 mg/kg once daily

Target Trough	Renal Function	Loading Dose			Maintenance Dose
		Day 1	Day 2	Day 3
15–30 μg/mL	eGFR >60	12 mg/kg q12h	12 mg/kg x1	12 mg/kg x1	6.0-6.7 mg/kg q24h
	eGFR 30–60	12 mg/kg q12h	10 mg/kg x1	6–6.7 mg/kg x1	3–3.3 mg/kg q24h
	eGFR <30	12 mg/kg q12h	5 mg/kg x1	5 mg/kg x1	5 mg/kg q48h
20–40 μg/mL	eGFR >60	12 mg/kg q12h	12 mg/kg q12h	12 mg/kg x1	6.0-6.7 mg/kg q24h
	eGFR 30–60	12 mg/kg q12h	12 mg/kg x1	12 mg/kg x1	5 mg/kg q24h
	eGFR <30	12 mg/kg q12h	12 mg/kg x1	6–6.7 mg/kg x1	3–3.3 mg/kg q24h
Hemodialysis (HD) • 此藥物不會被HD清除，按照 eGFR <30 mL/min 的劑量建議給藥即可

CRRT (CVVHDF)	Loading Dose			Maintenance Dose
	Day 1	Day 2	Day 3
Target 15–30 μg/mL	10 mg/kg q12h	10 mg/kg x1	10 mg/kg x1	3–3.3 mg/kg q24h
Target 20–40 μg/mL	12 mg/kg q12h	12 mg/kg x1	12 mg/kg x1

There are no dosage adjustments provided in the manufacturer's labeling. 【文字內容由仿單翻譯而來】

製備後應立即使用，有需要時應於冷藏2-8℃保存，24小時後則應丟棄