【缺藥訊息】 公告日期：2024/12/3 缺藥品項：TobraDEX 眼藥水 5 mL/Bot 缺藥原因：因廠商停產缺藥 配套措施：剩餘量保留慢箋回院調劑，請改用院內同類藥品替代。

眼用抗感染 Ocular inflammatory conditions:Treatment of steroid-responsive ocular inflammatory conditions (where either a superficial bacterial ocular infection or the risk of a bacterial ocular infection exists) of the palpebral and bulbar conjunctiva, cornea and anterior segment of the globe; chronic anterior uveitis; corneal injury from chemical, radiation or thermal burns; penetration of foreign bodies.

Tobramycin: Interferes with bacterial protein synthesis by binding to 30S ribosomal subunit resulting in a defective bacterial cell membrane.
Dexamethasone: Decreases inflammation by suppression of neutrophil migration, decreased production of inflammatory mediators, and reversal of increased capillary permeability; suppresses normal immune response.

See individual agents.

Hypersensitivity to tobramycin, dexamethasone, or any component of the formulation; viral diseases of the cornea and conjunctiva (including epithelial herpes simplex keratitis [dendritic keratitis], vaccinia, varicella); mycobacterial infection of the eye; fungal diseases of ocular structure.

C

It is not known if systemic absorption following topical administration results in detectable quantities in human milk. The manufacturer recommends that caution be exercised when administering tobramycin/dexamethasone to breast-feeding women. See individual agents.

Dermatologic: Allergic contact dermatitis
Infection: Secondary infection
Ophthalmic: Conjunctival erythema (<4%), eyelid pruritus (<4%), swelling of eye (<4%), cataract, glaucoma, increased intraocular pressure, keratitis, lacrimation, optic nerve damage
Miscellaneous: Wound healing impairment

Instill 1 to 2 drops into the conjunctival sac of the affected eye(s) every 4 to 6 hours; may be increased to 1 to 2 drops every 2 hours for the first 24 to 48 hours, then reduce to less frequent intervals as signs and symptoms improve.