藥碼
CAR14
藥名
臨採 Carnitine 咀嚼錠 1 gm
英文商品名
臨採 Carnitine 咀嚼錠 1 gm
中文商品名
加力體能咀嚼錠
螢幕名
臨採 Carnitine 咀嚼錠 1 gm
劑型
Tab
規格
成分
藥理分類
Caloric Drugs
健保碼
VC00006100
ATC碼
藥品圖片
外觀圖片
適應症
Primary systemic carnitine deficiency: Treatment of primary systemic carnitine deficiency.
Secondary carnitine deficiency: Acute and chronic treatment of patients with an inborn error of metabolism which results in a secondary carnitine deficiency.
藥理
Dietary Supplement
Carnitine is a naturally occurring metabolic compound which functions as a carrier molecule for long-chain fatty acids within the mitochondria, facilitating energy production. Carnitine deficiency is associated with accumulation of excess acyl CoA esters and disruption of intermediary metabolism.
藥動學
  • Protein binding: None
  • Metabolism: Hepatic; Major metabolites: Trimethylamine (TMA) and trimethylamine N-oxide (TMAO)
  • Bioavailability: Oral solution: 15.9% ± 4.9%; Tablet: 15.1% ± 5.3%
  • Half-life elimination: 17.4 hours
  • Time to peak: Oral: 3.3 hours
  • Excretion: Urine (76%, 4% to 8% as unchanged drug); feces (<1%)
  • 禁忌症
    There are no contraindications listed in the manufacturer's US labeling.
    Canadian labeling: Hypersensitivity to levocarnitine or any component of the formulation.
    懷孕分類
    Teratogenic effects were not observed in animal studies. Carnitine is a naturally occurring substance in mammalian metabolism.
    哺乳分類
    Use must be weighed against the potential exposure of the infant to increased carnitine intake.
    副作用
    Cardiovascular: Atrial fibrillation, chest pain, ECG abnormality, hypertension, palpitations, peripheral edema, tachycardia, vascular disease
    Dermatologic: Body odor, skin rash, urticaria
    Endocrine & metabolic: Hypercalcemia, parathyroid disorder, weight gain, weight loss
    Gastrointestinal: Abdominal cramps, abdominal pain, anorexia, diarrhea, dysgeusia, gastritis, melena, nausea, vomiting
    Hematologic & oncologic: Anemia, hemorrhage
    Hypersensitivity: Facial edema, hypersensitivity reaction (including anaphylaxis, bronchospasm, and laryngeal edema)
    Infection: Infection
    Nervous system: Asthenia, depression, dizziness, headache, myasthenia (uremic patients), paresthesia, seizure, vertigo
    Ophthalmic: Amblyopia, eye disease
    Renal: Renal failure syndrome
    Respiratory: Bronchitis, cough, rhinitis
    Miscellaneous: Fever
    劑量和給藥方法
    990 mg 2 to 3 times a day, depending on clinical response.
    小兒調整劑量
    Primary deficiency:
    Initial: 50 to 100 mg/kg/day in divided doses; reported frequency varies from 2 to 4 times daily up to every 3 to 4 hours; may titrate slowly as needed based on serum carnitine concentrations; reported range: 100 to 400 mg/kg/day; maximum daily dose: 3,000 mg/day.
    Secondary deficiency:
    Initial: 50 to 100 mg/kg/day in divided doses; reported frequency varies from 2 to 4 times daily up to every 3 to 4 hours; may titrate slowly as needed based on patient response; usual dose: 100 to 200 mg/kg/day; some patients may require higher doses (eg, 300 mg/kg/day); maximum daily dose: 3,000 mg/day.
    腎功能調整劑量
    There are no dosage adjustments provided in the manufacturer's labeling.
    肝功能調整劑量
    There are no dosage adjustments provided in the manufacturer's labeling; dosage adjustments should be determined by levocarnitine levels and clinical response.
    安定性
    藥袋資訊
    臨床用途
    先天遺傳性代謝異常的續發性CARNITINE缺乏病患之急性慢性治療
    主要副作用
    噁心、嘔吐、腹痛、腹瀉、皮膚紅疹、特殊體味等。
    泡製方法
    儲存方式
    請置於 15-30℃ 乾燥處儲存
    注意事項
    其他說明
    藥局 ADC | 藥庫 口管G
    藥品外觀
    顏色
    形狀
    01
    剝痕
    標記1
    標記2
    其他
    健保藥價
    131
    自費價
    174.23
    仿單
    資料庫
    健保給付規定